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Naphthalene Derivatives and Quinones from Ventilago denticulata and Their Nitric Oxide Radical Scavenging, Antioxidant, Cytotoxic, Antibacterial, and Phosphodiesterase Inhibitory Activities
Author(s) -
Molee Wannapha,
Phanumartwiwath Anuchit,
Kesornpun Chatchai,
Sureram Sanya,
Ngamrojanavanich Nattaya,
Ingkaninan Kornkanok,
Mahidol Chulabhorn,
Ruchirawat Somsak,
Kittakoop Prasat
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700537
Subject(s) - emodin , chemistry , dpph , anthraquinones , xanthine oxidase , antioxidant , nitric oxide , antibacterial activity , ic50 , hydroxyl radical , stereochemistry , biochemistry , organic chemistry , bacteria , enzyme , in vitro , botany , genetics , biology
New naphthalene derivatives ( 1 and 2 ) and a new isomer ( 3 ) of ventilagolin, together with known anthraquinones, chrysophanol ( 4 ), physcion or emodin 3‐methyl ether ( 5 ), and emodin ( 6 ), were isolated from vines of Ventilago denticulata . The isolated compounds exhibited cytotoxic activity with IC 50 values of 1.15 – 40.54 μg/ml. Compounds 1 – 3 selectively exhibited weak antibacterial activity ( MIC values of 200.0 – 400.0 μg/ml), while emodin ( 6 ) displayed moderate antibacterial activity with MIC value of 25.0 μg/ml. The isolated compounds showed nitric oxide and DPPH radical scavenging activities. Compounds 1 – 3 and 6 exhibited weak xanthine oxidase inhibitory activity, while emodin ( 6 ) acted as an aromatase inhibitor with the IC 50 value of 10.1 μ m . Compounds 1 and 2 exhibited phosphodiesterase 5 inhibitory activity with IC 50 values of 8.28 μ m and 6.48 μ m , respectively.