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Chemical Composition and Antimicrobial Activity of Ageratina deltoidea
Author(s) -
Arciniegas Amira,
PérezCastorena Ana L.,
MeléndezAguirre Mariana,
Ávila José Guillermo,
GarcíaBores Ana María,
Villaseñor José Luis,
Vivar Alfonso
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700529
Subject(s) - chemistry , antimicrobial , candida albicans , sesquiterpene , staphylococcus aureus , antibacterial activity , chlorogenic acid , escherichia coli , sesquiterpene lactone , corpus albicans , antifungal , stereochemistry , traditional medicine , organic chemistry , bacteria , biochemistry , microbiology and biotechnology , food science , biology , medicine , genetics , gene , yeast
The chemical study of Ageratina deltoidea afforded grandiflorenic acid ( 1 ), ent ‐kaurenoic acid ( 2 ), and eight benzylbenzoates ( 3 – 10 ), two of them, 3,5‐dimethoxybenzyl 2,3,6‐trimethoxybenzoate ( 5 ) and 4‐( β ‐ d ‐glucopyranosyloxy)‐3‐hydroxybenzyl 2,6‐dimethoxybenzoate ( 9 ), described for the first time. In addition, the new sesquiterpene lactone deltoidin C ( 13 ), together with the known 11 and 12 , the phenolic compounds: ayanin, 2,6‐dimethoxybenzoic acid, methyl 3,4‐dihydroxycinnamate, chlorogenic acid, and 3,5‐dicaffeoylquinic acid were also isolated. The structures of these compounds were determined by spectroscopic methods and chemical reactions. The antibacterial and antifungal activities of compounds 1 – 12 were evaluated on Staphylococcus aureus , Escherichia coli , and Candida albicans . Deltoidin A ( 11 ) was the most active antibacterial agent ( MIC 16.0 μg ml −1 ) against E. coli , and the ent ‐kaurenoid derivatives ( 1 – 2 ) showed activity ( MIC 31.0 μg ml −1 ) against S . aureus .