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Chemical Composition, Antioxidant and Anti‐melanogenic Activities of Essential Oils from Chrysanthemum boreale Makino at Different Harvesting Stages
Author(s) -
Kim DoYoon,
Won KyungJong,
Hwang Dae Il,
Park Soo Min,
Kim Bokyung,
Lee Hwan Myung
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700506
Subject(s) - chemistry , dpph , tyrosinase , antioxidant , melanin , food science , eugenol , essential oil , botany , biochemistry , biology , organic chemistry , enzyme
In the present study, the chemical compositions and skin whitening‐related antioxidant and anti‐melanogenic effect of essential oils ( EO s) extracted from Chrysanthemum boreale Makino ( CBM ) ( CBMEO s) at vegetative, pre‐flowering and full‐flowering are investigated and contrasted among the three stages. The yields and components of the CBMEO s were different at each stage. The CBMEO s increased DPPH and ABT s scavenging activities and attenuated the α ‐melanocyte stimulating hormone ( α ‐ MSH )‐induced tyrosinase activity and melanin synthesis in B16 BL 6 cells. Among CBMEO components, eugenol had the highest DPPH and ABT s scavenging activities and cuminaldehyde was the strongest inhibitor of α ‐ MSH ‐induced tyrosinase activity and melanin synthesis. The CBMEO s in each stage showed the different levels of phosphorylation of extracellular signal‐regulated kinase1/2 and p38 MAPK . These findings demonstrate that the CBMEO s have antioxidative and anti‐melanogenic activities in all the CBM harvesting stages, resulting in skin‐whitening biological activities and that the levels of their component contents and bioactivities differ among the CBM harvesting stages. The CBMEO s may have the potential for use in cosmetics and alternative medicine.