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Tricalycoside, a New Cerebroside from Tricalysia coriacea (Rubiaceae)
Author(s) -
Awouafack Maurice D.,
Tane Pierre,
Morita Hiroyuki
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700472
Subject(s) - chemistry , sephadex , silica gel , column chromatography , cerebroside , chromatography , rubiaceae , klebsiella pneumoniae , stereochemistry , organic chemistry , botany , biochemistry , escherichia coli , enzyme , gene , biology
A new cerebroside, named as tricalycoside ( 1 ), was isolated from the CH 2 Cl 2 /Me OH (1:1) extract of twigs and leaves of Tricalysia coriacea using repeated silica gel open column chromatography followed by preparative TLC and Sephadex LH ‐20 , together with six known compounds ( 2 – 7 ). The structure of the new compound was determined by analysis of 1D‐ and 2D‐ NMR , MS data, chemical conversion, and by comparison of these data with those from the literature. Tricalycoside ( 1 ) possessed a weak antibacterial activity against Klebsiella pneumoniae ( MIC = 75 μg/mL).
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