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Athenolide A, a New Steroidal Lactone from the Leaves of Athenaea martiana (Solanaceae) Determined by Means of HPLC ‐ HR ‐ MS ‐ SPE ‐ NMR Analysis
Author(s) -
Silva Eder L.,
AlmeidaLafetá Rita C.,
Borges Ricardo M.,
Staerk Dan
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700455
Subject(s) - chemistry , caffeic acid , vanillic acid , solanaceae , high performance liquid chromatography , genus , ferulic acid , stereochemistry , botany , chromatography , biochemistry , biology , antioxidant , gene
Athenaea (Solanaceae) is an endemic genus belonging to the Brazilian Atlantic Rainforest. Recently, botanical investigations suggested the re‐evaluation of the generic status of the genus Athenaea as a synonym of Aureliana . In this study, the first investigation of the Athenaea genus performed on Athenaea martiana by means of HPLC ‐ HR ‐ MS ‐ SPE ‐ NMR combined with high‐resolution radical scavenging profile led to identification of several phenolic acids as radical scavengers: protocatechuic acid ( 1 ), 4‐hydroxybenzoic acid ( 2 ), caffeic acid ( 3 ), vanillic acid ( 4 ), and ferulic acid ( 6 ). Additional analysis revealed a new steroidal lactone, named athenolide A ( 9 ). Their structures were elucidated by extensive use of NMR spectroscopy as well as HR ‐ MS . Chemotaxonomic considerations based on these results supported the chemical relationships between the Athenaea and Aureliana genera, in agreement with the recent botanical findings.