Varicuothiols A and B, New Fungal Metabolites from  Aspergillus versicolor  with Anti‐Inflammatory Activities | Zendy

Chen Ran | Zendy; Liu Dong | Zendy; Guo Peng | Zendy; Lin Wenhan | Zendy

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Varicuothiols A and B, New Fungal Metabolites from Aspergillus versicolor with Anti‐Inflammatory Activities

Author(s) -

Chen Ran,

Liu Dong,

Guo Peng,

Lin Wenhan

Publication year - 2018

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201700445

Subject(s) - aspergillus versicolor , chemistry , fungus , anti inflammatory , aspergillus , nitrite , microbiology and biotechnology , aspergillus fumigatus , stereochemistry , biochemistry , botany , organic chemistry , biology , pharmacology , nitrate

Chemical examination of a coral‐associated fungus Aspergillus versicolor LZD ‐44‐03 resulted in the isolation of two new compounds with the trivial names of varicuothiols A ( 1 ) and B ( 2 ) as a unique scaffold. Their structures were determined through extensive spectroscopic analyses in association with the modified Mosher 's method and chemical conversion. Both 1 and 2 exhibited significant inhibition against LPS ‐induced RAW 24.7 cell proliferation, in association with the down regulation of nitrite production and cytokines ( MCP ‐1, IL ‐6, and TNF ‐ α ).

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