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Varicuothiols A and B, New Fungal Metabolites from Aspergillus versicolor with Anti‐Inflammatory Activities
Author(s) -
Chen Ran,
Liu Dong,
Guo Peng,
Lin Wenhan
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700445
Subject(s) - aspergillus versicolor , chemistry , fungus , anti inflammatory , aspergillus , nitrite , microbiology and biotechnology , aspergillus fumigatus , stereochemistry , biochemistry , botany , organic chemistry , biology , pharmacology , nitrate
Chemical examination of a coral‐associated fungus Aspergillus versicolor LZD ‐44‐03 resulted in the isolation of two new compounds with the trivial names of varicuothiols A ( 1 ) and B ( 2 ) as a unique scaffold. Their structures were determined through extensive spectroscopic analyses in association with the modified Mosher 's method and chemical conversion. Both 1 and 2 exhibited significant inhibition against LPS ‐induced RAW 24.7 cell proliferation, in association with the down regulation of nitrite production and cytokines ( MCP ‐1, IL ‐6, and TNF ‐ α ).