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Eudesmanolides and Other Constituents from the Flowers of Wedelia trilobata
Author(s) -
Hui Yang,
Cao Jian,
Lin Jing,
Yang JianNi,
Liu YaJun,
Han ChangRi,
Song XiaoPing,
Dai ChunYan,
Zhang XiaoPeng,
Chen WenHao,
Chen GuangYing
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700411
Subject(s) - chemistry , hela , sesquiterpene , stereochemistry , cinnamic acid , two dimensional nuclear magnetic resonance spectroscopy , terpene , lytic cycle , terpenoid , organic chemistry , biochemistry , cell , biology , virus , virology
Two eudesmane sesquiterpene lactones, wedetrilides B ( 1 ) and C ( 2 ), along with five known analogues ( 3 – 8 ), an ent ‐kaurane diterpenoid ( 9 ), a steroid ( 10 ), as well as cinnamic acid derivatives ( 11 – 13 ), were isolated from the flowers of Wedelia trilobata . Their structures were elucidated on the basis of extensive spectroscopic analyses and by comparison of their NMR data with those of related compounds. Furthermore, the structures of 1 and 3 – 5 were confirmed by X‐ray single‐crystal diffraction analyses. Compounds 4 and 5 exhibited weak cytotoxic activities against the MCF ‐7, HeLa, and A549 cell lines. Compounds 3 – 5 were also evaluated for their inhibitory effects against HIV lytic replication.