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Antiviral Activity of Faramea hyacinthina and Faramea truncata Leaves on Dengue Virus Type‐2 and Their Major Compounds
Author(s) -
Barboza Rodolfo S.,
Valente Ligia M. M.,
Wolff Thiago,
AssunçãoMiranda Iranaia,
Neris Rômulo L. S.,
GuimarãesAndrade Iris P.,
Gomes Mário
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700393
Subject(s) - chemistry , rutin , stereochemistry , rubiaceae , epimer , dengue virus , quercetin , traditional medicine , virus , botany , biology , virology , biochemistry , medicine , antioxidant
The defatted fractions of the Faramea hyacinthina and F . truncata (Rubiaceae) leaf MeOH extracts showed in vitro non‐cytotoxic and anti‐dengue virus serotype 2 (DENV2) activity in human hepatocarcinoma cell lineage (HepG2). Submitting these fractions to the developed RP‐SPE method allowed isolating the antiviral flavanone (2 S )‐isosakuranetin‐7‐ O ‐ β ‐ d ‐apiofuranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 1 ) from both species and yielded less active sub‐fractions. The new diastereoisomeric epimer pair (2 S ) + (2 R ) of 5,3′,5′‐trihydroxyflavanone‐7‐ O ‐ β ‐ d ‐apiofuranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 2a / 2b ) from F . hyacinthina ; the known narigenin‐7‐ O ‐ β ‐ d ‐apiofuranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 3 ) from both species; rutin ( 4 ) and quercetin‐4′‐ β ‐ d ‐ O ‐glucopyranosyl‐3‐ O ‐rutinoside ( 5 ) from F . hyacinthina , and kaempferol‐3‐ O ‐rutinoside ( 6 ), erythroxyloside A ( 7 ) and asperuloside ( 8 ) from F . truncata have been isolated from these sub‐fractions. Compounds 4 – 8 are reported for the first time in Faramea spp.