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New Bioactive Macrocyclic Diterpenoids from Euphorbia helioscopia
Author(s) -
Hua Juan,
Luo ShiHong,
Liu Yan,
Liu YanChun,
Tan YanYun,
Feng Ling,
Xiao ChaoJiang,
Zhang KeQin,
Li ShengHong,
Niu XueMei
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700327
Subject(s) - plutella , chemistry , diterpene , cytotoxicity , helicoverpa armigera , stereochemistry , terpenoid , euphorbia , insect , euphorbiaceae , botany , lepidoptera genitalia , biology , biochemistry , in vitro
Three new macrocyclic diterpenoids, euphoscopoids A – C ( 1 – 3 ), including two new jatrophanes and a new lathyrane, were isolated from the whole plant of Euphorbia helioscopia . Their structures were elucidated by spectroscopic methods. Antifeedant and cytotoxic activities of these isolates were evaluated. All compounds showed significant antifeedant activity against a generalist plant‐feeding insect, Helicoverpa armigera , with EC 50 values ranging from 2.05 to 4.34 μg/cm 2 . In addition, compound 2 showed moderate cytotoxicity against tumor cell lines NCI ‐H1975, HepG2, and MCF ‐2, while compounds 1 and 3 were not active at 80 μ m . The results suggested not only the defensive function of macrocyclic diterpenoids in E. helioscopia against insect herbivores, but also their potential applications as new natural insect antifeedants.