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Effect of the Polyphenol Rich Ethyl Acetate Fraction from the Leaves of Lycium chinense Mill . on Oxidative Stress, Dyslipidemia, and Diabetes Mellitus in Streptozotocin‐Nicotinamide Induced Diabetic Rats
Author(s) -
Olatunji Opeyemi J.,
Chen Hongxia,
Zhou Yifeng
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700277
Subject(s) - chemistry , oxidative stress , streptozotocin , malondialdehyde , superoxide dismutase , aspartate transaminase , glutathione peroxidase , nicotinamide , diabetes mellitus , antioxidant , pharmacology , alkaline phosphatase , biochemistry , endocrinology , medicine , enzyme
Lycium chinense Mill ., popularly known as boxthorn, is a plant that is traditionally used for treating night sweat, cough, inflammation and diabetes mellitus. However, the leaves have received little or no attention despite their potentials as a potent therapeutic agent. This study was aimed at investigating the hypoglycemic and hypolipidemic effects of the polyphenols‐rich ethyl acetate fraction from the leaves of Lycium chinense Mill . on streptozotocin‐nicotinamide induced diabetic rats. The ethyl acetate fraction ( LFE ) was selected and orally gavaged at 100, 200, and 400 mg/kg dose to streptozotocin ( STZ )‐nicotinamide induced diabetic rats. The rats’ body weight, fasting blood glucose ( FBG ), lipid profile and oxidative stress markers were evaluated after the treatment period. Treatment with LFE resulted in a significant decrease in the FBG level, altered lipid profiles, and reduced the activities of the enzymes alkaline phosphatase ( ALP ), aspartate transaminase ( AST ), alanine transaminase ( ALT ) in the treated diabetic rats. Furthermore, LFE significantly elevated the antioxidant status (superoxide dismutase ( SOD ), catalase ( CAT ) and glutathione peroxidase ( GSH ‐Px) activities) and reducing malondialdehyde ( MDA ) levels in the treated rats. The present study has revealed that L. chinense Mill . possess anti‐hyperglycemic and anti‐hyperlipidemic properties which is mediated through modulation of oxidative stress and polyphenolics might be responsible for the action.