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New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera (J.F.G mel .) C.A. Sm .
Author(s) -
Simo Line Made,
Noté Olivier Placide,
Mbing Joséphine Ngo,
Aouazou Sarah Ali,
Guillaume Dominique,
Muller Christian Dominique,
Pegnyemb Dieudonné Emmanuel,
Lobstein Annelise
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700260
Subject(s) - chemistry , albizia , triterpenoid , cytotoxic t cell , traditional medicine , stereochemistry , biochemistry , in vitro , medicine
As part of our search for new bioactive saponins from Cameroonian medicinal plants, two new oleanane‐type saponins, named gummiferaosides D and E ( 1 and 2 ), along with one known saponin, julibroside J 8 ( 3 ), were isolated from the roots of Albizia gummifera . Their structures were established on the basis of extensive 1D‐ and 2D‐NMR ( 1 H‐ and 13 C‐NMR, DEPT, COSY, TOCSY, NOESY, HSQC, HSQC‐TOCSY, and HMBC) and HR‐ESI‐MS studies, and by chemical evidence. The apoptotic effect of saponins 1 – 3 was evaluated on the A431 human epidermoid cancer cell. Flow cytometric analyses showed that saponins 1 – 3 induced apoptosis of human epidermoid cancer cell (A431) in a dose‐dependent manner.