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Structural Modification of Stilbenoids from Acanthopanax leucorrhizus and Their Cytotoxic Activity
Author(s) -
Hu HaoBin,
Liang HaiPeng,
Li HaiMing,
Yuan RuNan,
Sun Jiao,
Wu Yun,
Zhang LaLa,
Han MingHu
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700244
Subject(s) - hela , chemistry , cytotoxic t cell , resveratrol , in vitro , stereochemistry , cytotoxicity , cell culture , mtt assay , traditional medicine , biochemistry , biology , medicine , genetics
A new cis ‐stilbenoid, 1,9‐dihydroxy‐10‐methoxy‐6 H ‐dibenzo[ b , f ]oxocin‐6‐one ( 2 ) was isolated from the Ac OE t extract of the stem barks of Acanthopanax leucorrhizus , along with three known stilbenoids, 9‐hydroxy‐10‐methoxy‐6 H ‐dibenzo[ b , f ]oxocin‐6‐one ( 1 ), 5‐ O ‐methyl‐( E )‐resveratrol 3‐ O ‐ β ‐ d ‐glucopyranoside ( 3 ), and ( E )‐resveratrol 3‐ O ‐ β ‐ d ‐xylopyranoside ( 4 ). Two derivatives ( 2a and 2b ) were synthesized by the structural modification of compound 2, which exhibited certain cytotoxic activities against HT ‐29 and HeLa cell lines in vitro . All compounds were structurally characterized by comprehensive analysis of their spectroscopic data and comparison with literature information, and evaluated for their cytotoxic activities against three human tumor cell lines ( HL ‐60, HT ‐29, and HeLa) by the standard MTT assay in vitro . The results showed that derivatives 2a and 2b exhibited strong activities than compounds 2 against HT ‐29 and HeLa cell lines.