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Angupyrones A – E, α ‐Pyrone Analogues with ARE ‐Activation from a Sponge‐Associated Fungus Truncatella angustata
Author(s) -
Zhao Yang,
Liu Dong,
Proksch Peter,
Yu Siwang,
Lin Wenhan
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700236
Subject(s) - chemistry , sponge , pyrone , fungus , stereochemistry , dpph , fractionation , antioxidant , organic chemistry , botany , biology
TLC ‐ DPPH guided fractionation of a sponge‐associated fungus Truncatella angustata with a solid culture resulted in the isolation of five new α ‐pyrone‐based analogues namely angupyrones A – E ( 1 – 5 ), and 3‐ethyl‐4‐hydroxy‐6‐methyl‐2‐pyrone. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher 's method, bulkiness rule, and specific rotation for the configurational assignments. Angupyrones A – E exhibited moderate antioxidant response element activation in HepG2C8 cells, while the preliminary structure‐activity relationship was discussed.