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α ‐Glucosidase Inhibitory Xanthones from the Roots of Garcinia fusca
Author(s) -
Nguyen Nam K.,
Truong Xuyen A.,
Bui Thai Q.,
Bui Dzung N.,
Nguyen Hai X.,
Tran Phuong T.,
Nguyen LienHoa D.
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700232
Subject(s) - acarbose , chemistry , ic50 , ethyl acetate , stereochemistry , garcinia , two dimensional nuclear magnetic resonance spectroscopy , traditional medicine , organic chemistry , biochemistry , in vitro , enzyme , medicine
Two new compounds, fuscaxanthones J ( 1 ) and K ( 2 ), together with eight known xanthones ( 3 – 10 ) were isolated from an ethyl acetate extract of the roots of Garcinia fusca . Their structures were determined using spectroscopic methods, mainly 1D‐ and 2D‐ NMR . α ‐Glucosidase inhibitory activity of the isolated compounds was evaluated and fuscaxanthone J ( 1 ) showed the most significant effect with an IC 50 value of 8.3 ± 1.8 μ m (compared with acarbose, IC 50 = 214.5 ± 2.3 μ m ).