α ‐Glucosidase Inhibitory Xanthones from the Roots of  Garcinia fusca | Zendy

Nguyen Nam K. | Zendy; Truong Xuyen A. | Zendy; Bui Thai Q. | Zendy; Bui Dzung N. | Zendy; Nguyen Hai X. | Zendy; Tran Phuong T. | Zendy; Nguyen LienHoa D. | Zendy

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α ‐Glucosidase Inhibitory Xanthones from the Roots of Garcinia fusca

Author(s) -

Nguyen Nam K.,

Truong Xuyen A.,

Bui Thai Q.,

Bui Dzung N.,

Nguyen Hai X.,

Tran Phuong T.,

Nguyen LienHoa D.

Publication year - 2017

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201700232

Subject(s) - acarbose , chemistry , ic50 , ethyl acetate , stereochemistry , garcinia , two dimensional nuclear magnetic resonance spectroscopy , traditional medicine , organic chemistry , biochemistry , in vitro , enzyme , medicine

Two new compounds, fuscaxanthones J ( 1 ) and K ( 2 ), together with eight known xanthones ( 3 – 10 ) were isolated from an ethyl acetate extract of the roots of Garcinia fusca . Their structures were determined using spectroscopic methods, mainly 1D‐ and 2D‐ NMR . α ‐Glucosidase inhibitory activity of the isolated compounds was evaluated and fuscaxanthone J ( 1 ) showed the most significant effect with an IC 50 value of 8.3 ± 1.8 μ m (compared with acarbose, IC 50 = 214.5 ± 2.3 μ m ).

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