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Bioactive Neolignans and Other Compounds from Magnolia grandiflora L.: Isolation and Antiplasmodial Activity
Author(s) -
Latif Abdul,
Du Yongle,
Dalal Seema R.,
FernándezMurga Maria L.,
Merino Emilio F.,
Cassera Maria B.,
Goetz Michael,
Kingston David G. I.
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700209
Subject(s) - magnoliaceae , chemistry , isolation (microbiology) , traditional medicine , botany , stereochemistry , biology , microbiology and biotechnology , medicine
Bioassay‐guided fractionation of a methanol extract of Magnolia grandiflora against Plasmodium falciparum yielded two new ( 1 and 2 ) and six known ( 3 – 8 ) bioactive compounds. The structures of the new compounds were assigned by mass spectrometric and 1D‐ and 2D‐ NMR data. Known compounds were identified by comparison of 1 H‐ NMR and MS data with literature data. The two known neolignans 3 and 4 showed moderate antiplasmodial activity with the IC 50 values of 2.8 ± 0.1 and 3.4 ± 0.1 μ m , respectively. Weak antiplasmodial activity was recorded for compounds 1 , 2 , 5 , 6 , 7 , and 8 , with the IC 50 values of 38 ± 2, 23 ± 2, 16.5 ± 0.2, 86 ± 1, 44 ± 4, and 114 ± 9 μ m , respectively.