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A Novel Tropoloisoquinoline Alkaloid, Neotatarine, from Acorus calamus L.
Author(s) -
Li Juan,
Li ZhaoXing,
Zhao JianPing,
Wang Wei,
Zhao XiaoFang,
Xu Bo,
Li Lin,
Zhang Lan,
Ren Jie,
Khan Ikhlas A.,
Li ShunXiang
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700201
Subject(s) - acorus calamus , alkaloid , rhizome , chemistry , calamus , traditional medicine , stereochemistry , botany , biology , medicine
A novel tropoloisoquinoline alkaloid, neotatarine ( 1 ), was isolated from the 95% ethanol extract of the rhizome parts of Acorus calamus L. The chemical structure was unambiguously elucidated by spectroscopic and single‐crystal X‐ray diffraction analysis. Neotatarine ( 1 ) exhibited significantly inhibitory activity against A β 25 – 35 induced PC 12 cell death with 2, 4 and 8 μ m comparing with the assay control ( P < 0.01).