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New Prenylated ortho ‐Dihydroxycoumarins from the Fruits of Ficus nipponica
Author(s) -
Akihara Yui,
Ohta Emi,
Nehira Tatsuo,
Ômura Hisashi,
Ohta Shinji
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700196
Subject(s) - ficus , prenylation , chemistry , bacillus subtilis , coumarin , antibacterial activity , botany , stereochemistry , bark (sound) , traditional medicine , bacteria , biology , organic chemistry , enzyme , medicine , genetics , ecology
Two new prenylated ortho ‐dihydroxycoumarins, designated fipsomin ( 1 ) and fipsotwin ( 2 ), were isolated from the fruits of Ficus nipponica together with a known prenylated coumarin, apigravin ( 3 ). Their structures were established by spectroscopic data and X‐ray crystallographic analysis. Compound 1 exhibited antibacterial activity against Bacillus subtilis with an MIC value of 61 μ m , while 2 and 3 showed very weak activity.