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Two New Sesquiterpene Alcohols Isolated from Senecio hadiensis Forssk . Grown in Saudi Arabia
Author(s) -
Ahmed Sarfaraz,
Ahmad Mohammad Shamim,
Yousaf Muhammad,
NureAlam Mohammad,
AlRehaily Adnan J.
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700144
Subject(s) - sesquiterpene , phytochemical , chemistry , stereochemistry , senecio , terpene , in vitro , traditional medicine , botany , biochemistry , biology , medicine
Phytochemical investigation on the aerial parts of Senecio hadiensis Forssk . led to the isolation of two new sesquiterpenoids, presilphiperfolan‐2 α ,5 α ,8 α ‐triol ( 1 ) and presilphiperfolan‐2 α ,5 α ,8 α ,10 α ‐tetraol ( 2 ) featuring the rare presilphiperfolane‐type frameworks. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic (1D‐ and 2D‐ NMR , HR ‐ ESI ‐ MS ) methods and by comparison with the literature data. The isolates 1 and 2 were evaluated in‐vitro for antiinflammatory, cytotoxic, and peroxisome proliferator activated receptor alpha and gamma ( PPAR α and PPAR γ ) agonistic activities.