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Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT‐A37
Author(s) -
Ding Hui,
Wang JiaNan,
Zhang DaShan,
Ma ZhongJun
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700140
Subject(s) - chemistry , antimicrobial , escherichia coli , streptomyces , strain (injury) , staphylococcus aureus , cytotoxicity , bacteria , ic50 , stereochemistry , minimum inhibitory concentration , inhibitory postsynaptic potential , cytotoxic t cell , microbiology and biotechnology , biochemistry , in vitro , gene , organic chemistry , biology , genetics , anatomy , neuroscience
On the basis of the one strain–many compounds strategy, five compounds including two new holomycin derivatives 2 – 3 , two new cyclopropaneacetic acid derivatives 4 – 5 , together with one known compound holomycin ( 1 ) were isolated from a marine‐derived bacterium Streptomyces sp. DT‐A37. Their structures were elucidated using NMR and HR‐ESI‐MS analyses. All these compounds were evaluated for their antimicrobial activity, cytotoxic activity, and inhibitory activity against BRD4 protein. Compound 1 exhibited potent cytotoxicity against H1975 cells with IC 50 value of 1 μ m , and its minimal inhibitory concentration values against Escherichia coli and Staphylococcus aureus were both 64 μ m .