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Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells
Author(s) -
Basso Ana Valentina,
Leiva González Segundo,
Barboza Gloria Estela,
Careaga Valeria Pilar,
Calvo Juan Carlos,
Sacca Paula A.,
Nicotra Viviana Estela
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700118
Subject(s) - subfamily , phytochemical , biology , botany , solanaceae , taxon , genus , traditional medicine , gene , biochemistry , medicine
Twelve Salpichroa taxa have been phytochemically analyzed. From the aerial parts of S . scandens , four known salpichrolides A, C, I, S, and an unreported withanolide named salpichrolide V ( 1 ), were isolated. In S . dependens , S . gayi , S . glandulosa subsp. glandulosa , S . glandulosa subps. weddellii , S . leucantha , S . micrantha , S . microloba , S . proboscidea , S . ramosissima , S . tristis var. tristis , and S . weberbauerii , no withanolides were found. The chemical content of ca . 85% of the Salpichroa taxa is in agreement with molecular studies, which suggest that Salpichroa and Jaborosa , a genus considered morphologically close to Salpichroa , are distant in the systematic of the Solanoideae subfamily. Moreover, the in vitro cytotoxic activity of a set of natural salpichrolides and derivatives was examined against two prostate carcinoma cell lines ( PC 3 and LNC aP) and two human breast cancer cell lines ( MCF ‐7 and T47D). Several compounds showed moderate activity ( IC 50 = 64.91 – 29.97 μ m ).