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Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives
Author(s) -
Burmudžija Adrijana Z.,
Muškinja Jovana M.,
Kosanić Marijana M.,
Ranković Branislav R.,
Novaković Slađana B.,
Đorđević Snežana B.,
Stanojković Tatjana P.,
Baskić Dejan D.,
Ratković Zoran R.
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700077
Subject(s) - hela , antimicrobial , chemistry , cytotoxic t cell , cell culture , in vitro , stereochemistry , a549 cell , biochemistry , organic chemistry , biology , genetics
A small series of 1‐acetyl‐2‐(4‐alkoxy‐3‐methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4‐(4‐hydroxy‐3‐methoxyphenyl)‐3‐buten‐2‐one) and its O ‐alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS 174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line ( MRC 5). Butyl derivative is the most active on HeLa cells ( IC 50 = 8.63 μ m ), while benzyl one is active against LS 174 and A549 cell lines ( IC 50 = 10.17 and 12.15 μ m , respectively).