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New Cytotoxic Alkylated Chalcones from Fatoua villosa
Author(s) -
Su ShiYun,
Xue JingJing,
Yang GuangYu,
Lei Chun,
Hou AiJun
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700076
Subject(s) - chemistry , alkylation , cytotoxicity , stereochemistry , villosa , cytotoxic t cell , ic50 , in vitro , organic chemistry , biochemistry , botany , biology , catalysis
Three new alkylated chalcones, villosins A – C ( 1 – 3 ), five known analogues, together with ten known coumarins, were isolated from Fatoua villosa . The structures of the new compounds were elucidated by extensive spectroscopic analysis, including 1D‐, 2D‐ NMR , and MS data. Compounds 1 – 3 showed cytotoxicity against five kinds of human tumor cell lines ( NB 4, A549, SHSY 5Y, PC 3, and MCF 7) with IC 50 values ranging from 1.4 ± 0.1 to 5.7 ± 0.3 μ m .