New Cytotoxic Alkylated Chalcones from  Fatoua villosa | Zendy

Su ShiYun | Zendy; Xue JingJing | Zendy; Yang GuangYu | Zendy; Lei Chun | Zendy; Hou AiJun | Zendy

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New Cytotoxic Alkylated Chalcones from Fatoua villosa

Author(s) -

Su ShiYun,

Xue JingJing,

Yang GuangYu,

Lei Chun,

Hou AiJun

Publication year - 2017

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201700076

Subject(s) - chemistry , alkylation , cytotoxicity , stereochemistry , villosa , cytotoxic t cell , ic50 , in vitro , organic chemistry , biochemistry , botany , biology , catalysis

Three new alkylated chalcones, villosins A – C ( 1 – 3 ), five known analogues, together with ten known coumarins, were isolated from Fatoua villosa . The structures of the new compounds were elucidated by extensive spectroscopic analysis, including 1D‐, 2D‐ NMR , and MS data. Compounds 1 – 3 showed cytotoxicity against five kinds of human tumor cell lines ( NB 4, A549, SHSY 5Y, PC 3, and MCF 7) with IC 50 values ranging from 1.4 ± 0.1 to 5.7 ± 0.3 μ m .

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