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Four New Diterpene Glucosides from Perovskia atriplicifolia
Author(s) -
Gao Lu,
Zhou Jun,
Zhu LeYu,
Zhang JuanRong,
Jing YuXing,
Zhao JiaWen,
Huang XiangZhong,
Li GanPeng,
Jiang ZhiYong,
Xue DaYuan
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700071
Subject(s) - diterpene , hela , chemistry , cytotoxic t cell , stereochemistry , hl60 , two dimensional nuclear magnetic resonance spectroscopy , cytotoxicity , biochemistry , cell , in vitro
Four new diterpene glucosides, namely perovskiaditerpenosides A – D ( 1 – 4 ), were isolated from the BuOH extract of Perovskia atriplicifolia . Their structures were well elucidated by chemical methods and comprehensive spectroscopic analyses including MS, IR, and NMR (1D and 2D). The newly isolated compounds were screened for their cytotoxic activity against HepG2, NB4, HeLa, K562, MCF7, PC3, and HL60. The obtained results indicated that the new compounds possessed considerable cytotoxic activity.