Premium
New Resorcinol Derivatives from a Sponge‐Derived Fungus Hansfordia sinuosae
Author(s) -
Wu Zehong,
Li Yuan,
Liu Dong,
Ma Min,
Chen Jianliang,
Lin Wenhan
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700059
Subject(s) - chemistry , resorcinol , cytotoxicity , mass spectrometry , abts , sponge , fungus , stereochemistry , antioxidant , organic chemistry , nuclear chemistry , chromatography , dpph , biochemistry , in vitro , botany , biology
Ten new resorcinol derivatives named hansfordiols A – J ( 1 – 10 ) were isolated from the fermentation broth of the sponge‐derived fungus Hansfordia sinuosae . High resolution electron ionization mass spectrometry, FT ‐ IR spectroscopy, and NMR techniques were used to elucidate the structures of these compounds, and the absolute configurations were established by the modified Mosher 's method and their specific optical rotation. The structures of compounds 8 – 10 were featured with various chlorination at aromatic rings. Their antioxidant activities on ABTS , cytotoxicity on the HCT ‐8, Bel‐7402, BGC ‐823, A549, and A2780 cell lines, and antibacterial activities were evaluated.