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New Avermectin Analogues from a Mutant Streptomyces avermectinius Strain
Author(s) -
Zhang Youjun,
Zhang Cheng,
Wang Keke,
Chen Guoliang,
Sun Peng
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700054
Subject(s) - avermectin , chemistry , strain (injury) , streptomyces , mutant , stereochemistry , biochemistry , genetics , gene , bacteria , biology , anatomy
Two new avemectin analogues 1 and 2 belonging to ‘b’ series of components were isolated from a ∆ave CDE mutant Streptomyces avermectinius strain. Their structures were elucidated by detailed analysis of NMR and MS spectroscopic data. Compounds 1 and 2 displayed moderate cytotoxicities against B16, MG ‐63, and Saos‐2 cell lines in an in vitro assay.