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Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV 2 Cells
Author(s) -
Nhiem Nguyen Xuan,
Tuong Nguyen Trung,
Ky Pham Thanh,
Subedi Lalita,
Park Seon Ju,
Ngoc Tran Minh,
Yen Pham Hai,
Tai Bui Huu,
Quang Tran Hong,
Kiem Phan Van,
Kim Sun Yeou,
Kim Seung Hyun
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700013
Subject(s) - chemistry , nitric oxide , inhibitory postsynaptic potential , biochemistry , stereochemistry , organic chemistry , biology , neuroscience
Phaeanthus vietnamensis B ân is a well‐known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7 S ,8 R ,8′ R )‐9,9′‐epoxy‐3,5,3′,5′‐tetramethoxylignan‐4,4′,7‐triol ( 1 ), 8 α ‐hydroxyoplop‐11(12)‐en‐14‐one ( 5 ), and (1 R ,2 S ,4 S )‐4‐acetyl‐2‐[( E )‐(cinnamoyloxy)]‐1‐methylcyclohexan‐1‐ol ( 12 ) along with twelve known compounds were isolated from the leaves of P . vietnamensis . Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS ‐stimulated BV 2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS ‐stimulated NO production in BV 2 cells with the IC 50 values of 15.7 ± 1.2 μ m . Compounds 2 , 7 , and 8 significantly inhibited inflammatory NO production with IC 50 values ranging from 22.6 to 25.3 μ m .