Premium
Composition, Antifungal and Antiproliferative Activities of the Hydrodistilled Oils from Leaves and Flower Heads of Pterocephalus nestorianus N ábělek
Author(s) -
Abdullah Fuad O.,
Hussain Faiq H. S.,
Mannucci Barbara,
Lappano Rosamaria,
Tosi Solveig,
Maggiolini Marcello,
Vidari Giovanni
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700009
Subject(s) - chemistry , myristic acid , lauric acid , candida tropicalis , linalool , fungicide , minimum inhibitory concentration , candida albicans , food science , essential oil , traditional medicine , dermatophyte , botany , fatty acid , antimicrobial , yeast , biology , biochemistry , organic chemistry , palmitic acid , medicine
This article reports the first study of the chemical composition, and antifungal and antiproliferative properties of the volatile extracts obtained by hydrodistillation of the flower heads and leaves of the traditional Kurdish medicinal plant Pterocephalus nestorianus N ábělek , collected in the wild. A total of 55 constituents, 43 of the flower heads’ oil ( PFO ) and 46 of the leaves’ oil ( PLO ), respectively, were identified by GC / MS , constituting 99.68% and 99.04% of the two oils, respectively. The oils were obtained in 0.15% and 0.10% yields ( w / w ), respectively, on air‐dried vegetable material. The prevalent constituents of the PFO were α ‐terpineol (2.41%), α ‐linalool (6.42%), 6,10,14‐trimethylpentadecan‐2‐one (2.59%), myristic acid (24.65%), and lauric acid (50.44%), while the major components of PLO were ( E )‐hex‐2‐enal (2.26%), ( E )‐hex‐2‐en‐1‐ol (2.04), myristic acid (34.03%), and lauric acid (50.35%). The two oils showed significant inhibitory and fungicidal activities against the medically important fungi Candida albicans , Candida tropicalis , Microsporum canis , and Trichophyton mentagrophytes , with minimum inhibitory concentration ranging from 0.7 to 3.3 mg/ml and minimum fungicidal concentration varying from 1.4 to 6.6 mg/ml. The antiproliferative activity of the two oils was assayed against one normal and six human tumor cell lines. Both oils showed selective cytotoxic activity, with IC 50 values ranging from 1.4 to 3.3 μg/ml.