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Exploratory Studies on the in Vitro Anti‐inflammatory Potential of Two Herbal Teas ( Annona muricata L. and Jasminum grandiflorum L.), and Relation with Their Phenolic Composition
Author(s) -
Oliveira Andreia P.,
Sá Ivone,
Pereira David M.,
Gonçalves Rui F.,
Andrade Paula B.,
Valentão Patrícia
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700002
Subject(s) - annona muricata , chemistry , traditional medicine , annona , composition (language) , botany , biology , annonaceae , medicine , philosophy , linguistics
The need of new anti‐inflammatory drugs has led to the search for safer and more potent molecules in distinct sources, such as natural products. This work aimed to explore the anti‐inflammatory potential of aqueous extracts from two herbal teas ( Annona muricata L. and Jasminum grandiflorum L.) in RAW 264.7 macrophages cells and in cell‐free assays. Furthermore, the phenolic composition of both extracts and of their hydrolysates was characterized by HPLC ‐ DAD , in order to establish possible relationships with the biological activity. In a general way, A. muricata displayed a stronger capacity to inhibit nitric oxide ( NO ) production and the activity of phospholipase A 2 ( PLA 2 ), displaying an IC 50 value of 142 μg/ml against this enzyme. A deeper look at phenolic compounds revealed that aglycones had more capacity to inhibit NO and PLA 2 than their corresponding glycosides, quercetin being clearly the most potent one ( IC 50 = 7.47 and 1.36 μ m , respectively). In addition, 5‐ O ‐caffeoylquinic acid, at 1.56 μ m , could also inhibit PLA 2 ( ca . 35%). Our findings suggest that the consumption of both herbal teas may be a preventive approach to inflammatory disorders.