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Antileishmanial Activity and Immunomodulatory Effects of Tricin Isolated from Leaves of Casearia arborea (Salicaceae)
Author(s) -
Santos Augusto L.,
Yamamoto Eduardo S.,
Passero Luiz Felipe D.,
Laurenti Márcia D.,
Martins Ligia F.,
Lima Marta L.,
Uemi Miriam,
Soares Marisi G.,
Lago João Henrique G.,
Tempone Andre G.,
Sartorelli Patricia
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201600458
Subject(s) - tricin , chemistry , amastigote , salicaceae , traditional medicine , biochemistry , leishmania , botany , biology , woody plant , parasite hosting , medicine , flavonoid , world wide web , computer science , antioxidant
Bioactivity‐guided fractionation of antileishmanial active extract from leaves of Casearia arborea led to isolation of three metabolites: tricin ( 1 ), 1′,6′‐di‐ O ‐ β ‐ d ‐vanilloyl glucopyranoside ( 2 ) and vanillic acid ( 3 ). Compound 1 demonstrated the highest activity against the intracellular amastigotes of Leishmania infantum , with an IC 50 value of 56 μ m . Tricin ( 1 ) demonstrated selectivity in mammalian cells ( SI > 7) and elicited immunomodulatory effect on host cells. The present work suggests that tricin modulated the respiratory burst of macrophages to a leishmanicidal state, contributing to the parasite elimination. Therefore, the natural compound tricin could be further explored in drug design studies for leishmaniasis treatment.