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Oleanane‐ type Saponins from Glochidion hirsutum and Their Cytotoxic Activities
Author(s) -
Thang Nguyen Van,
Thu Vu Kim,
Nhiem Nguyen Xuan,
Dung Duong Thi,
Quang Tran Hong,
Tai Bui Huu,
Anh Hoang Le Tuan,
Yen Pham Hai,
Ngan Nguyen Thi Thanh,
Hoang Nguyen Huy,
Kiem Phan Van
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201600445
Subject(s) - cytotoxic t cell , chemistry , oleanane , stereochemistry , cytotoxicity , cancer cell lines , cell culture , cancer cell , cancer , biochemistry , in vitro , biology , medicine , triterpene , pathology , alternative medicine , genetics
Five new oleanane‐ type saponins, hirsutosides A – E, were isolated from the leaves of Glochidion hirsutum ( Roxb .) Voigt . Their structures were elucidated as 21 β ‐benzoyloxy‐3 β ,16 β ,23,28‐tetrahydroxyolean‐12‐ene 3 ‐O‐β ‐ d ‐glucopyranoside ( 1 ), 21 β ‐benzoyloxy‐3 β ,16 β ,23,28‐tetrahydroxyolean‐12‐ene 3 ‐O‐β ‐ d ‐glucopyranosyl‐(1 → 3) ‐β ‐ d ‐glucopyranoside ( 2 ), 21 β ‐benzoyloxy‐3 β ,16 β ,23,28‐tetrahydroxyolean‐12‐ene 3 ‐O‐ 6‐acetyl‐[ β ‐ d ‐glucopyranosyl‐(1 → 3)] ‐β ‐ d ‐glucopyranoside ( 3 ), 21 β ‐benzoyloxy‐3 β ,16 β ,23,28‐tetrahydroxyolean‐12‐ene 3 ‐O‐β ‐ d ‐glucopyranosyl‐(1 → 3) ‐〈 ‐ l ‐arabinopyranoside ( 4 ), and 21 β ‐benzoyloxy‐3 β ,16 β ,23‐trihydroxyolean‐12‐ene‐28‐al 3 ‐O‐β ‐ d ‐glucopyranosyl‐(1 → 3) ‐α ‐ l ‐arabinopyranoside ( 5 ). All isolated compounds were evaluated for cytotoxic activities on four human cancer cell lines, HepG‐2, A‐549, MCF ‐7, and SW ‐626 using the SRB assay. Compounds 1 , 2 , 4 , and 5 showed significant cytotoxic activities against all human cancer cell lines with IC 50 values ranging from 3.4 to 10.2 μ m . Compound 3 containing acetyl group at glc C(6″) exhibited weak cytotoxic activity with IC 50 values ranging from 47.0 to 54.4 μ m .