New Furanone Derivatives and Alkaloids from the Co‐Culture of Marine‐Derived Fungi  Aspergillus sclerotiorum  and  Penicillium citrinum | Zendy

Bao Jie | Zendy; Wang Jie | Zendy; Zhang XiaoYong | Zendy; g XuHua | Zendy; Qi ShuHua | Zendy

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New Furanone Derivatives and Alkaloids from the Co‐Culture of Marine‐Derived Fungi Aspergillus sclerotiorum and Penicillium citrinum

Author(s) -

Bao Jie,

Wang Jie,

Zhang XiaoYong,

g XuHua,

Qi ShuHua

Publication year - 2017

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201600327

Subject(s) - penicillium citrinum , chemistry , penicillium , aspergillus , marine fungi , botany , aspergillus flavus , biology , food science

Six new compounds including two furanone derivatives sclerotiorumins A and B ( 1 and 2 ), one novel oxadiazin derivative sclerotiorumin C ( 3 ), one pyrrole derivative 1‐(4‐benzyl‐1 H ‐pyrrol‐3‐yl)ethanone ( 4 ), and two complexes of neoaspergillic acid aluminiumneohydroxyaspergillin ( 5 ) and ferrineohydroxyaspergillin ( 6 ) were isolated from the co‐culture of marine‐derived fungi Aspergillus sclerotiorum and Penicillium citrinum . Compound 3 was the first natural 1,2,4‐oxadiazin‐6‐one. Compound 5 showed significant and selective cytotoxicity against human histiocytic lymphoma U937 cell line ( IC 50 = 4.2 μ m ) and strong toxicity towards brine shrimp ( LC 50 = 6.1 μ m ), and oppositely increased the growth and biofilm formation of Staphylococcus aureus .

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