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New Furanone Derivatives and Alkaloids from the Co‐Culture of Marine‐Derived Fungi Aspergillus sclerotiorum and Penicillium citrinum
Author(s) -
Bao Jie,
Wang Jie,
Zhang XiaoYong,
g XuHua,
Qi ShuHua
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201600327
Subject(s) - penicillium citrinum , chemistry , penicillium , aspergillus , marine fungi , botany , aspergillus flavus , biology , food science
Six new compounds including two furanone derivatives sclerotiorumins A and B ( 1 and 2 ), one novel oxadiazin derivative sclerotiorumin C ( 3 ), one pyrrole derivative 1‐(4‐benzyl‐1 H ‐pyrrol‐3‐yl)ethanone ( 4 ), and two complexes of neoaspergillic acid aluminiumneohydroxyaspergillin ( 5 ) and ferrineohydroxyaspergillin ( 6 ) were isolated from the co‐culture of marine‐derived fungi Aspergillus sclerotiorum and Penicillium citrinum . Compound 3 was the first natural 1,2,4‐oxadiazin‐6‐one. Compound 5 showed significant and selective cytotoxicity against human histiocytic lymphoma U937 cell line ( IC 50 = 4.2 μ m ) and strong toxicity towards brine shrimp ( LC 50 = 6.1 μ m ), and oppositely increased the growth and biofilm formation of Staphylococcus aureus .