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Essential Oil of Thymus munbyanus subsp. coloratus from Algeria: Chemotypification and in vitro Biological Activities
Author(s) -
Bendif Hamdi,
Boudjeniba Messaoud,
Miara Mohamed Djamel,
Biqiku Loreta,
Bramucci Massimo,
Lupidi Giulio,
Quassinti Luana,
Vitali Luca A.,
Maggi Filippo
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201600299
Subject(s) - chemotype , essential oil , phytochemical , lamiaceae , antimicrobial , antimycobacterial , antibacterial activity , abts , botany , traditional medicine , biology , dpph , cytotoxicity , borneol , chemistry , microbiology and biotechnology , antioxidant , bacteria , in vitro , biochemistry , mycobacterium tuberculosis , medicine , tuberculosis , genetics , alternative medicine , pathology , traditional chinese medicine
Thymus munbyanus subsp. coloratus (Lamiaceae) is a small shrub endemic to Algeria and Morocco where is found in lawns, rockeries and mountainous regions. From a phytochemical point of view this taxon has never been characterized. In this work we have analysed the chemical compositions of the essential oils obtained from inflorescences and vegetative parts by GC/MS. A new chemotype, i.e . borneol‐chemotype, was characterized for the first time in the species. Furthermore, we assessed the biological activities of essential oils, namely the antioxidant, antimicrobial and cytotoxicity on tumor cells that were evaluated by the DPPH, ABTS, and FRAP, disc diffusion, and MTT methods, respectively. Biological assays highlighted a moderate inhibitory effect on Staphylococcus aureus , Escherichia coli and Candida albicans (inhibition zone diameter in the range 9 – 10 mm), and noteworthy cytotoxicity on A375 human melanoma cells ( IC 50 of 46.95 μg/ml).