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A New Iridoid Dimer and Other Constituents from the Traditional Kurdish Plant Pterocephalus nestorianus Nábělek
Author(s) -
Abdullah Fuad O.,
Hussain Faiq H. S.,
Clericuzio Marco,
Porta Alessio,
Vidari Giovanni
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201600281
Subject(s) - dimer , chemistry , iridoid , stereochemistry , kaempferol , traditional medicine , biochemistry , flavonoid , organic chemistry , glycoside , medicine , antioxidant
Accompanied by other rare compounds, a new iridoid dimer, named kurdnestorianoside ( 1 ), showing an unprecedented secologanol configuration, has been isolated for the first time from the Kurdish medicinal plant Pterocephalus nestorianus , which is used in Kurdistan for treating oral diseases and inflammation. The structure of 1 was established from 1D‐ and 2D‐ NMR spectroscopic data. Kaempferol 3‐ O ‐[3,6‐di‐ O ‐( E )‐ p ‐coumaroyl]‐ β ‐ d ‐glucopyranoside ( 7 ) showed a remarkable antiproliferative activity against several human tumor cell lines.