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Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation
Author(s) -
Alves Iura M.,
Abreu Lucas S.,
Costa Cinara O. S.,
Le Hyaric Mireille,
Guedes Maria Lenise S.,
Soares Milena B. P.,
Bezerra Daniel P.,
Velozo Eudes S.
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201600276
Subject(s) - chromone , chemistry , cytotoxic t cell , hl60 , stereochemistry , limonin , ether , limonoid , peripheral blood mononuclear cell , ic50 , cell culture , cytotoxicity , cell , biochemistry , in vitro , organic chemistry , biology , genetics
One new chromone 3,3‐dimethylallylspatheliachromene methyl ether ( 1 ), as well as five known chromones, 6‐(3‐methylbut‐2‐enyl) allopteroxylin methyl ether ( 2 ), 6‐(3‐methylbut‐2‐enyl) allopteroxylin ( 3 ), 3,3‐dimethylallylspatheliachromene ( 4 ), 5‐ O ‐methylcneorumchromone K ( 5 ) and spatheliabischromene ( 6 ), two alkaloids, 8‐methoxy‐ N ‐methylflindersine ( 7 ) and 8‐methoxyflindersine ( 8 ), and two limonoids, limonin diosphenol ( 9 ) and rutaevin ( 10 ), were isolated from Dictyoloma vandellianum A. Juss (Rutaceae). Cytotoxic activities towards tumor cell lines B16‐F10, HepG2, K562 and HL60 and non‐tumor cells PBMC were evaluated for compounds 1 – 6 . Compound 1 was the most active showing IC 50 values ranging from 6.26 to 14.82 μg/ml in B16‐F10 and K562 cell lines, respectively, and presented IC 50 value of 11.65 μg/ml in PBMC cell line.
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