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Synthesis and Anticancer Activity of 3‐(Substituted Aroyl)‐4‐(3,4,5‐trimethoxyphenyl)‐1 H ‐pyrrole Derivatives
Author(s) -
Zhan XiaoPing,
Lan Lan,
Wang Shuai,
Zhao Kai,
Xin YuXuan,
Qi Qi,
Wang YaoLin,
Mao ZhenMin
Publication year - 2017
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201600219
Subject(s) - hela , chemistry , ic50 , cytotoxicity , pyrrole , mtt assay , stereochemistry , cell culture , cancer cell , in vitro , pharmacology , combinatorial chemistry , biochemistry , cancer , organic chemistry , biology , genetics
A series of 3‐(substituted aroyl)‐4‐(3,4,5‐trimethoxyphenyl)‐1 H ‐pyrrole derivatives were synthesized and determined for their anticancer activity against eleven cancer cell lines and two normal tissue cell lines using MTT assay. Among the synthesized compounds, compound 3f was the most potent compound against A375, CT ‐26, HeLa, MGC 80‐3, NCI ‐H460 and SGC ‐7901 cells ( IC 50 = 8.2 – 31.7 μ m ); 3g , 3n and 3a were the most potent compounds against CHO ( IC 50 = 8.2 μ m ), HCT ‐15 ( IC 50 = 21 μ m ) and MCF ‐7 cells ( IC 50 = 18.7 μ m ), respectively. Importantly, all the target compounds showed no cytotoxicity towards the normal tissue cell ( IC 50 > 100 μ m ). Thus, these compounds with the potent anticancer activity and low toxicity have potential for the development of new anticancer chemotherapy agents.