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Evaluation of Antioxidant, Anticholinesterase, and Antidiabetic Potential of Dry Leaves and Stems in Tamarix aphylla Growing Wild in Tunisia
Author(s) -
Mahfoudhi Adel,
Grosso Clara,
Gonçalves Rui F.,
Khelifi Eltaief,
Hammami Saoussen,
Achour Sami,
TrabelsiAyadi Malika,
Valentão Patrícia,
Andrade Paula B.,
Mighri Zine
Publication year - 2016
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201600157
Subject(s) - chemistry , dpph , quercetin , kaempferol , astringent , antioxidant , traditional medicine , food science , botany , biochemistry , medicine , biology , taste
Tamarix aphylla (L.) Karst . has a wide geographic distribution and was employed in traditional medicine as astringent, anti‐rheumatic and to treat fever. T . aphylla leaves and stems extracts were studied from both chemical and biological points of view to assess the antidiabetic, anticholinesterase and antioxidant potential of this species. The HPLC/Diode Array Detector (DAD) analysis showed the presence of 14 phenolic compounds (gallic, caffeic, p ‐coumaric, ferulic and ellagic acids, kaempferol, quercetin, quercetin 3‐ O ‐galactoside and six flavonol derivatives). This is the first study reporting a comparative study of the biological activities of different extracts from T . aphylla . High activities were obtained against DPPH radical, superoxide anion radical ( O 2 ∙ − ) and nitric oxide radical ( • NO) in a concentration‐dependent manner, the most active extracts being the polar ones. T . aphylla also showed moderate protective effects against acetylcholinesterase, but no effects were observed against butyrylcholinesterase. Against α ‐glucosidase the MeOH extracts displayed IC 50 values from 8.41 to 24.81 μg/ml.