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Chemical Variability and Biological Activities of Essential Oils of Micromeria inodora ( Desf .) Benth . from Algeria
Author(s) -
Benomari Fatima Zahra,
Djabou Nassim,
Medbouhi Ali,
Khadir Abdelmounaim,
Bendahou Mourad,
Selles Chaouki,
Desjobert JeanMarie,
Costa Jean,
Muselli Alain
Publication year - 2016
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201600098
Subject(s) - essential oil , bacillus cereus , chemistry , cereus , enterococcus faecalis , food science , bacillus subtilis , staphylococcus aureus , agar diffusion test , bacteria , botany , biology , genetics
The chemical composition of the essential oils isolated from the aerial parts of Micromeria inodora ( Desf .) Benth . collected in 24 Algerian localities was investigated from the first time using GC ‐ FID , GC / MS and 13 C‐ NMR . Altogether, 83 components which accounted for 94.7% of the total oil composition were identified. The main compounds were trans ‐sesquisabinene hydrate ( 1 ; 20.9%), α ‐terpinyl acetate ( 2 ; 19.8%), globulol ( 3 ; 4.9%), caryophyllene oxide ( 4 ; 4.3%), β ‐bisabolol ( 5 ; 2.9%) and trans ‐7‐epi‐sesquisabinene hydrate ( 6 ; 2.6%). Comparison with the literature highlighted the originality of the Algerian M . inodora oil and indicated that 1 might be used as taxonomical marker. The study of the chemical variability allowed the discrimination of two main clusters confirming that there is a relation between the essential‐oil compositions and the soil nature of the harvest locations. Biological activity of M . inodora essential oil was assessed against fourteen species of microorganisms involved in nosocomial infections using paper disc diffusion and dilution agar assays. The in vitro study demonstrated a good activity against Gram ‐positive strains such as Staphylococcus aureus, Bacillus cereus , Bacillus subtilis , and Enterococcus faecalis, and moderate activity against Candida albicans . These results might be useful for the future commercial valorization of M . inodora essential oil as a promising source of natural products with potential against various nosocomial community and toxinic infections.