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New Cytotoxic Bibenzyl and Other Constituents from Bauhinia ungulata L. (Fabaceae)
Author(s) -
Sousa Leôncio M.,
Carvalho Jarbas L.,
Silva Horlando C.,
Lemos Telma L. G.,
Arriaga Angela M. C.,
BrazFilho Raimundo,
Militão Gardênia C. G.,
Silva Thiago D. S.,
Ribeiro Paulo R. V.,
Santiago Gilvandete M. P.
Publication year - 2016
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201600058
Subject(s) - fabaceae , bibenzyl , chemistry , cytotoxic t cell , botany , traditional medicine , stereochemistry , biology , biochemistry , medicine , in vitro
A new bibenzyl, 2′‐hydroxy‐3,5‐dimethoxy‐4‐methylbibenzyl ( 1 ) and four known compounds identified as 2′‐hydroxy‐3,5‐dimethoxybibenzyl ( 2 ), liquiritigenin ( 3 ), guibourtinidol ( 4 ) and fisetinidol ( 5 ) were isolated from the roots of Bauhinia ungulata L. Phytochemical investigations of the stems of B . ungulata led to the isolation of the known compounds identified as liquiritigenin ( 3 ), guibourtinidol ( 4 ), fisetinidol ( 5 ), taraxerol ( 6 ), betulinic acid ( 7 ), taraxerone ( 8 ), glutinol ( 9 ), a mixture of sitosterol ( 10 ) and stigmasterol ( 11 ), pacharin ( 12 ), naringenin ( 13 ) and eriodictyol ( 14 ). The structures of these compounds were elucidated on the basis of their spectral data ( IR , MS , 1D‐ and 2D‐ NMR ). The cytotoxicity of the bibenzyl 1 has been evaluated against four human cancer cell lines, showing the IC 50 values of 4.3 and 6.5 μg ml −1 against pro‐myelocytic leukemia ( HL ‐60) and cervical adenocarcinoma ( HEP ‐2) cell lines, respectively. This article also registers for the first time the 13 C‐ NMR data of the known bibenzyl 2 .