Premium
Isocoumarin Derivatives from the Sponge‐Associated Fungus Peyronellaea glomerata with Antioxidant Activities
Author(s) -
Zhao Yang,
Liu Dong,
Proksch Peter,
Yu Siwang,
Lin Wenhan
Publication year - 2016
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201600012
Subject(s) - isocoumarin , isocoumarins , chemistry , stereochemistry , fungus , sponge , pentane , biochemistry , organic chemistry , botany , catalysis , biology
Chemical examination of the solid culture of the sponge‐associated fungus Peyronellaea glomerata led to the isolation of five new isocoumarins, namely peyroisocoumarins A – D ( 1 – 4 ) and isocitreoisocoumarinol ( 5 ), together with 13 known analogues ( 6 – 18 ). Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher 's method for the configurational assignments. Peyroisocoumarins A and B were characterized by the presence of Cl‐atom at pentane chain, which were unusual in isocoumarin derivatives. The ARE reporter assay revealed that peyroisocoumarins A, B, and D exerted potent ARE activation in HepG2C8 cells, while the preliminary analyses of structure–activity relationship was discussed.