Bioactive Coumarins from the Stems of Clausena emarginata

Five new coumarins, clauemarmarins I – M ( 1 – 4 ), together with 10 known analogs ( 5 – 14 ), were isolated from the stems of Clausena emarginata . Compounds 8 – 13 were obtained from this plant for the first time. Their structures were established and elucidated by comprehensive analysis of spectroscopic data. The absolute configurations of 1 – 4 were further determined by their electronic circular dichroism spectroscopy. Compounds 5 , 7 , 12 , and 14 exhibited inhibitory effects on LPS‐induced NO production. Compounds 5 – 7 showed selective neuroprotective effects in A β 25 – 35 model at 10 μ m .