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Bioactive Coumarins from the Stems of Clausena emarginata
Author(s) -
Ouyang GuoQing,
Li ChuangJun,
Yang JingZhi,
Li Li,
Song XiuYun,
Jiang YiNa,
Chen NaiHong,
Ma Jie,
Zhang DongMing
Publication year - 2016
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201500519
Subject(s) - chemistry , circular dichroism , stereochemistry
Five new coumarins, clauemarmarins I – M ( 1 – 4 ), together with 10 known analogs ( 5 – 14 ), were isolated from the stems of Clausena emarginata . Compounds 8 – 13 were obtained from this plant for the first time. Their structures were established and elucidated by comprehensive analysis of spectroscopic data. The absolute configurations of 1 – 4 were further determined by their electronic circular dichroism spectroscopy. Compounds 5 , 7 , 12 , and 14 exhibited inhibitory effects on LPS‐induced NO production. Compounds 5 – 7 showed selective neuroprotective effects in A β 25 – 35 model at 10 μ m .