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New Thymoquinol Glycosides and Neuroprotective Dibenzocyclooctane Lignans from the Rattan Stems of Schisandra chinensis
Author(s) -
Yang BingYou,
Guo JiangTao,
Li ZuYi,
Wang ChangFu,
Wang ZhiBin,
Wang QiuHong,
Kuang HaiXue
Publication year - 2016
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201500311
Subject(s) - schisandra chinensis , rattan , chemistry , glycoside , schisandra , neuroprotection , traditional medicine , botany , pharmacology , stereochemistry , biology , medicine , alternative medicine , pathology , traditional chinese medicine
Three new lignans ( 1 – 3 ), together with four new thymoquinol glycosides ( 4 – 7 ), were isolated from 70%‐Et OH extract of the rattan stems of Schisandra chinensis . The structures of 1 – 7 were elucidated by detailed spectroscopic analyses, and these new compounds were identified as pinobatol‐9‐ O ‐ β ‐ d ‐glucopyranoside ( 1 ), 1,2,13,14‐tetramethoxydibenzocyclooctadiene 3,12‐ O ‐ β ‐ d ‐diglucopyranoside ( 2 ), 3,7‐dihydroxy‐1,2,13,14‐tetramethoxydibenzocyclooctadiene 12‐ O ‐ β ‐ d ‐glucopyranoside ( 3 ), thymoquinol 2‐ O ‐ β ‐ d ‐apiofuranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 4 ), thymoquinol 2‐ O ‐ α ‐ d ‐arabinofuranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 5 ), thymoquinol 5‐ O ‐ β ‐ d ‐apiofuranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 6 ), and thymoquinol 5‐ O ‐ α ‐ d ‐arabinofuranosyl‐(1→6)‐ β ‐ d ‐glucopyranoside ( 7 ). The neuroprotective activity of 1 – 7 was evaluated on PC 12 cells with neurotoxicity induced by amyloid‐beta 1 – 42 (A β 1 – 42 ). Compounds 2 and 3 showed protecting activity against A β ‐induced toxicity in PC 12 cells.