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Identification and Biological Activities of Long‐Chain Peptaibols Produced by a Marine‐Derived Strain of Trichoderma longibrachiatum
Author(s) -
MohamedBenkada Mustapha,
François Pouchus Yves,
Vérité Philippe,
Pagniez Fabrice,
Caroff Nathalie,
Ruiz Nicolas
Publication year - 2016
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201500159
Subject(s) - chemistry , electrospray ionization , agar , mytilus , antifungal , microbiology and biotechnology , mass spectrometry , chromatography , biology , ecology , bacteria , genetics
Six long‐chain peptaibols, 1  –  6 , were identified from agar cultures of a marine‐derived Trichoderma longibrachiatum Rifai strain ( MMS 151) isolated from blue mussels. The structure elucidation was carried out using electrospray ionization ion trap mass spectrometry ( ESI ‐ IT ‐ MS ) and GC / EI ‐ MS . The long‐chain peptaibols exhibited the general building scheme Ac‐Aib‐Ala‐Aib‐Ala‐Aib‐ XXX ‐Gln‐Aib‐Vxx‐Aib‐Gly‐ XXX ‐Aib‐Pro‐Vxx‐Aib‐ XXX ‐Gln‐Gln‐Pheol and were similar or identical to recurrent 20‐residue peptaibols produced by Trichoderma spp. Three new sequences were identified and were called longibrachins A‐0, A‐ II ‐a, and A‐ IV ‐b. The isolated peptaibols were assayed for cytotoxic, antibacterial, and antifungal activities, and acute toxicity on Dipteran larvae.

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