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New Alkaloids and α ‐Glucosidase Inhibitory Flavonoids from Ficus hispida
Author(s) -
Shi ZhengFeng,
Lei Chun,
Yu BangWei,
Wang HeYao,
Hou AiJun
Publication year - 2016
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201500142
Subject(s) - alkaloid , chemistry , stereochemistry , ficus , biochanin a , pyrrolidine , indolizidine , traditional medicine , isoflavones , botany , biochemistry , biology , genistein , medicine , daidzein , endocrinology
Two new pyrrolidine alkaloids, ficushispimines A ( 1 ) and B ( 2 ), a new ω ‐(dimethylamino)caprophenone alkaloid, ficushispimine C ( 3 ), and a new indolizidine alkaloid, ficushispidine ( 4 ), together with the known alkaloid 5 and 11 known isoprenylated flavonoids 6 – 16 , were isolated from the twigs of Ficus hispida . Their structures were elucidated by spectroscopic methods. Isoderrone ( 8 ), 3′‐(3‐methylbut‐2‐en‐1‐yl)biochanin A ( 11 ), myrsininone A ( 12 ), ficusin A ( 13 ), and 4′,5,7‐trihydroxy‐6‐[(1 R *,6 R *)‐3‐methyl‐6‐(1‐methylethenyl)cyclohex‐2‐en‐1‐yl]isoflavone ( 14 ) showed inhibitory effects on α ‐glucosidase in vitro .