New Alkaloids and  α ‐Glucosidase Inhibitory Flavonoids from  Ficus hispida | Zendy

Shi ZhengFeng | Zendy; Lei Chun | Zendy; Yu BangWei | Zendy; Wang HeYao | Zendy; Hou AiJun | Zendy

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New Alkaloids and α ‐Glucosidase Inhibitory Flavonoids from Ficus hispida

Author(s) -

Shi ZhengFeng,

Lei Chun,

Yu BangWei,

Wang HeYao,

Hou AiJun

Publication year - 2016

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201500142

Subject(s) - alkaloid , chemistry , stereochemistry , ficus , biochanin a , pyrrolidine , indolizidine , traditional medicine , isoflavones , botany , biochemistry , biology , genistein , medicine , daidzein , endocrinology

Two new pyrrolidine alkaloids, ficushispimines A ( 1 ) and B ( 2 ), a new ω ‐(dimethylamino)caprophenone alkaloid, ficushispimine C ( 3 ), and a new indolizidine alkaloid, ficushispidine ( 4 ), together with the known alkaloid 5 and 11 known isoprenylated flavonoids 6 – 16 , were isolated from the twigs of Ficus hispida . Their structures were elucidated by spectroscopic methods. Isoderrone ( 8 ), 3′‐(3‐methylbut‐2‐en‐1‐yl)biochanin A ( 11 ), myrsininone A ( 12 ), ficusin A ( 13 ), and 4′,5,7‐trihydroxy‐6‐[(1 R *,6 R *)‐3‐methyl‐6‐(1‐methylethenyl)cyclohex‐2‐en‐1‐yl]isoflavone ( 14 ) showed inhibitory effects on α ‐glucosidase in vitro .

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