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Herbicidal and Cytotoxic Constituents from Aralia armata ( Wall .) Seem .
Author(s) -
Miao Hui,
Sun Yongyan,
Yuan Yunfei,
Zhao Huanhuan,
Wu Jiao,
Zhang Weiyun,
Zhou Lijuan
Publication year - 2016
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201500130
Subject(s) - chemistry , bidens pilosa , spodoptera litura , glycoside , cytotoxicity , stereochemistry , cell growth , phytochemical , terpene , traditional medicine , biochemistry , botany , biology , in vitro , medicine , larva
Two new triterpenoids, 3 β ‐hydroxyoleana‐11,13(18)‐diene‐28,30‐dioic acid ( 1 ) and 3‐oxooleana‐11,13(18)‐diene‐28,30‐dioic acid ( 2 ), one novel triterpenoid glycoside, 3 β ‐ O ‐(6′‐ O ‐methyl‐ β ‐ d‐ glucuronopyranosyl)oleana‐11,13(18)‐dien‐28‐oic acid ( 3 ) along with six known compounds ( 4 – 9 ) were isolated from the stem bark of Aralia armata ( Wall .) Seem . Their structures were elucidated through extensive spectroscopic methods. The herbicidal activities of these compounds against Bidens pilosa L., an invasive weed in P. R. China, were evaluated. Compounds 3 , 5, and 6 exhibited more significant herbicidal activities on B. pilosa than the positive‐control pendimethalin. Their possible use as herbicidal chemicals or model compounds deserved more attention. The effects of compounds 1 – 9 on Spodoptera litura cultured cell line Sl‐1 cell proliferation and its morphology were also evaluated. The results indicated that compounds 1 – 5 affected Sl‐1 cell proliferation. Compound 3 showed more obvious proliferation inhibition activities on Sl‐1 cell than the positive‐control rotenone. With regard to the effect on morphology, compound 2 significantly changed Sl‐1 cell, resulting in cell blebbing and vacuole forming. Triterpenoids aremedicinally and agriculturally important, and cytotoxicity of the three new compounds 1 – 3 deserved further studies.