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Chaephilones A and B, Two New Azaphilone Derivatives Isolated from Chaetomium globosum
Author(s) -
Chen Chunmei,
Wang Jing,
Zhu Hucheng,
Wang Jianping,
Xue Yongbo,
Wei Guangzheng,
Guo Yi,
Tan Dongdong,
Zhang Jinwen,
Yin Chunping,
Zhang Yonghui
Publication year - 2016
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201500117
Subject(s) - chaetomium globosum , chemistry , microbiology and biotechnology , botany , biology
Two new azaphilone derivatives, chaephilones A ( 1 ) and B ( 2 ), were isolated from the fungus Chaetomium globosum , together with four structurally related analogs 3 – 6 . The structures of 1 and 2 were elucidated by comprehensive spectroscopic analyses including HR ‐ ESI ‐ MS and NMR . The known compounds were identified as chaetomugilin Q ( 3 ), chaetomugilin D ( 4 ), 11‐epichaetomugilin A ( 5 ), and chaetomugilin S ( 6 ) by comparing their NMR data and optical rotation values with those reported. Compound 2 represents the first example of azaphilone with an open furan ring. Compounds 1 and 2 were evaluated for cytotoxic activities against five human cancer cell lines ( HL ‐60, SMMC ‐7721, A‐549, MCF ‐7, and SW 480) by the MTS method.