Mitsunobu Alkylation of Cancerostatic 5‐Fluorouridine with (2 E )‐10‐Hydroxydec‐2‐enoic Acid, a Fatty Acid from Royal Jelly with Multiple Biological Activities

5‐Fluorouridine ( 1 ) – a nucleoside antimetabolite with strong cancerostatic properties – was protected i ) at the 2′‐ and 3′‐OH groups with a heptan‐4‐ylidene residue and ii ) at the 5′‐OH group with a (4‐methoxyphenyl)(diphenyl)methyl residue. This fully protected compound, 3 , was submitted to a Mitsunobu reaction with the N ‐hydroxysuccinimide (NHS) ester, 5 , of (2 E )‐10‐hydroxydec‐2‐enoic acid ( 4 ) which gave nucleolipid 6 . The latter was detritylated with Cl 2 CHCOOH to yield the co‐drug 7 as NHS ester.