Premium
α ‐Glucosidase Inhibitors from the Fungus Aspergillus terreus 3.05358
Author(s) -
Shan WeiGuang,
Wu ZhaoYing,
Pang WeiWei,
Ma LieFeng,
Ying YouMin,
Zhan ZhaJun
Publication year - 2015
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201500027
Subject(s) - aspergillus terreus , acarbose , chemistry , fungus , stereochemistry , aspergillus , alkaloid , absolute configuration , two dimensional nuclear magnetic resonance spectroscopy , enzyme , biochemistry , microbiology and biotechnology , botany , biology
One new diketopiperazine alkaloid amauromine B ( 1 ), along with three known meroterpenoids, austalide B ( 2 ), austalides N and O ( 3 and 4 ), and two known steroids ( 5 and 6 ), was isolated and identified from the culture broth of the fungus Aspergillus terreus 3.05358. Their structures were elucidated by extensive spectroscopic techniques, including 2D‐NMR and MS analysis, the absolute configuration of 1 was unambiguously established by single crystal X‐ray diffraction analysis. All the isolates were evaluated for their inhibitory effects on α ‐glucosidase. Amauromine B ( 1 ) and austalide N ( 3 ) exhibited more potent α ‐glucosidase inhibitory activities than the positive control acarbose.