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Polyketides from Mantis‐Associated Fungus Daldinia eschscholzii IFB‐TL01
Author(s) -
Wang Gang,
Fan JingYang,
Zhang WenJing,
Hua ChengPin,
Chen ChaoJun,
Yan Wei,
Ge HuiMing,
Jiao RuiHua,
Tan RenXiang
Publication year - 2015
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201400414
Subject(s) - chemistry , fungus , stereochemistry , ic50 , in vitro , biochemistry , botany , biology
Three new polyketides, named daldinone F ( 1 ), nodulisporin G ( 2 ), and dalmanol C ( 3 ), together with five known compounds, 4 – 8 , were isolated from cultures of Daldinia eschscholzii. The structures of the new compounds were elucidated by extensive NMR and MS analyses. Compound 1 showed moderate cytotoxic activity against SW480 cancer cells with an IC 50 value of 9.59 μ M , and its absolute configuration was determined by single crystal X‐ray diffraction.