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Netamines O–S, Five New Tricyclic Guanidine Alkaloids from the Madagascar Sponge Biemna laboutei , and Their Antimalarial Activities
Author(s) -
Gros Emmanuelle,
Martin MarieThérèse,
Sorres Jonathan,
Moriou Céline,
Vacelet Jean,
Frederich Michel,
Aknin Maurice,
Kashman Yoel,
GauvinBialecki Anne,
AlMourabit Ali
Publication year - 2015
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201400350
Subject(s) - tricyclic , guanidine , sponge , plasmodium falciparum , chemistry , stereochemistry , cytotoxic t cell , parasite hosting , malaria , biology , biochemistry , in vitro , botany , immunology , world wide web , computer science
In our continuing program to isolate new compounds from the Madagascar sponge Biemna laboutei , five new tricyclic guanidine alkaloids, netamines O – S ( 1 – 5 , resp.), have been identified together with the known compounds netamine E ( 6 ) and mirabilin J ( 7 ). The structures of all new netamines were assigned on the basis of spectroscopic analyses. Their relative configurations were established by analysis of ROESY data and comparison with literature data. Netamines O, P, and Q, which were isolated in sufficient quantities, were tested for their cytotoxic activities against KB cells and their activities against the malaria parasite Plasmodium falciparum. Netamines O and Q were found to be moderately cytotoxic. Netamines O, P, and Q exhibited antiplasmodial activities with IC 50 values of 16.99±4.12, 32.62±3.44, and 8.37±1.35 μ M , respectively.