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Secondary Metabolites from Aspergillus fumigatus , an Endophytic Fungus from the Liverwort Heteroscyphus tener ( Steph .) Schiffn .
Author(s) -
Xie Fei,
Li XiaoBin,
Zhou JinChuan,
Xu QingQing,
Wang XiaoNing,
Yuan HuiQing,
Lou HongXiang
Publication year - 2015
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201400317
Subject(s) - aspergillus fumigatus , fungus , chemistry , aspergillus , plant use of endophytic fungi in defense , cytotoxicity , microbiology and biotechnology , cancer cell lines , stereochemistry , botany , biology , biochemistry , cancer , cancer cell , in vitro , genetics
Three new metabolites, asperfumigatin ( 1 ), isochaetominine ( 10 ), and 8′‐ O ‐methylasterric acid ( 21 ), together with nineteen known compounds, were obtained from the culture of Aspergillus fumigatus , an endophytic fungus from the Chinese liverwort Heteroscyphus tener ( Steph.) Schiffn. Their structures were established by extensive analysis of the spectroscopic data. The absolute configurations of 1 and 10 were determined by analysis of their respective CD spectra. Cytotoxicity of these isolates against four human cancer cell lines was also determined.